![]() Taurine is a necessary nutrient for cats and foxes (Schaffer and Kim, 2018). ![]() Taurine has low water solubility, is naturally acidic, and has a pKa value of 1.5 (Jakaria et al., 2019). Pharmacological actions of taurine include membrane stabilization, cytoprotective and anti-inflammatory effects, regulation of intracellular calcium ions, and regulation of neurotransmitter levels (Adedara et al., 2017). It also contributes to homeostasis by modulating glutamatergic signaling and preventing excitotoxicity and oxidative stress. Taurine is an inhibitory neurotransmitter that acts as an agonist at γ-amino butyric acid (GABA) and glycine receptors, modulates Ca 2+ influx, and is an intracellular secondary messenger (Liu et al., 2022). Given the strong evidence for the neuropharmacological efficacy of taurine in various experimental paradigms, it is concluded that this molecule should be considered and further investigated as a potential candidate for neurotherapeutics, with emphasis on mechanism and clinical studies to determine efficacy.Ĭhemical structure and a molecular formula of taurine (2-aminoethanesulfonic acid). This article is a good resource for understanding the general effects of taurine on various diseases. The general neuroprotective effects of taurine and the various possible underlying mechanisms are discussed in this review. The design of taurine formation could lead to potential drugs/supplements for the health maintenance and treatment of central nervous system disorders. Approximately 30 million people are affected worldwide. ![]() Although various therapies are available, effective management of these disorders remains a global challenge. Taurine effectively protects against a number of neurological disorders, including stroke, epilepsy, cerebral ischemia, memory dysfunction, and spinal cord injury. As part of its limiting functions, taurine also modulates endoplasmic reticulum stress, Ca 2+ homeostasis, and neuronal activity at the molecular level. It alternates between inflammation and oxidative stress-mediated injury in various disease models. Taurine is a sulfur-containing, semi-essential amino acid that occurs naturally in the body.
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